Steven and Tyler at Bay 3 Console

Our laboratory is interested in examining structural and functional changes in the brain due to aging and neurodegenerative diseases. A primary focus of this work is to determine how the common decline in vascular health with advancing age contributes to neurodegenerative changes, cognitive attenuation and the development of dementia and HD. We utilize novel neuroimaging methods (based on magnetic resonance imaging and positron emission tomography) as primary tools to measure subtle alterations in tissue integrity and physiology, and integrate these measures with assessments of cognitive function and systemic physiology. Through these studies, we hope to advance procedures for the clinical utilization of imaging technology in the diagnosis, characterization and tracking of neurodegenerative disease as well as towards advancing understanding of the pathological mechanisms that cause Alzheimer's disease and neurodegenerative conditions in general.